Penrith's uniform colours in the 1966 NSWRL Second Division and earlier years were blue and white but due to the Cronulla-Sutherland side registering a predominantly blue jersey design first, and with Newtown, Canterbury, Eastern Suburbs and Parramatta also displaying various shades of blue, Penrith went in search of an alternative. A decision was made to change their colours to Brown with a white V. This decision subsequently earned them the affectionate name of the "Chocolate Soldiers" thanks to radio commentator Frank Hyde who wrote in the Penrith Club journal "these chocolate soldiers from out west – they don't melt!".
The team had been referred to as the 'Panthers' as early as 1970.
In 1974 Penrith changed their strip to a jerseys with brown and white vertical bars and again in 1991 they changed the colours to Black with White, Red, Yellow and Green stripes (drawing another confectionery-related nickname, the Liquorice Allsorts) until 1997 when Super League had all new jersey
Just before Christmas 2007 the Panthers launched a new 'home' jersey which is predominately black with light grey claw marks on either side at the front and back. For Season 2010, the Panthers have launched a new predominantly teal away jersey, this teal jersey connect with the away jersey from their 03 and 04 season's. With their official colours still Black, Teal green and rust red the alternate jersey was chosen to represent their secondary colour. The inception of Teal into the colour palet of Panthers links directly back to the unique colour their 2nd division jerseys had before brown and white.
In late October, 2010, the Panthers announced that rust would no longer be a secondary colour for the club. A new jersey was also launched, black with grey claw marks on either side. The club's teal jersey was also scratched in Round 4, 2011, when a new white jersey with grey claw marks and teal and black stripes was announced the club's new alternate jersey.
For the 2014 season the Panthers wore a redesigned black home jersey while the white away jersey prominently displays the new club logo. The Pink Jersey was also retained as a 3rd alternate strip, and used for Women in League and Breast Cancer Awareness rounds, or when both strips would clash with the opposing side. There was also a special Indigenous Jersey, worn in round 23 for the Indigenous Awareness round.